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Embracing Results-Driven Discovery

by Lewis Martin

June 17, 2021

June 2, 2021 marked 10 years since Anthony Nicholls published his sensible, skeptical blog post “Avoiding Hype-based Science,” in which he advised what—and what not—to do when making technology decisions in preclinical drug discovery.

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Embracing Results-Driven Discovery

858 Therapeutics and OpenBench Launch Small Molecule Drug Discovery Collaboration

November 4, 2024

SAN DIEGO & SAN FRANCISCO--(BUSINESS WIRE)--858 Therapeutics and OpenBench today announced a collaboration to discover small molecule inhibitors using OpenBench’s structure-based machine learning platform. The collaboration will focus initially on an undisclosed target nominated by 858 Therapeutics. [...]

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858 Therapeutics and OpenBench Launch Small Molecule Drug Discovery Collaboration

OpenBench and ORIC Pharmaceuticals Launch Success-Driven Discovery Collaboration

September 17, 2024

SAN FRANCISCO, Sept. 17, 2024 /PRNewswire/ -- OpenBench, Inc., a pioneer in AI-enabled success-driven small molecule discovery partnerships, today announced the launch of a collaboration with ORIC Pharmaceuticals, Inc. (NASDAQ: ORIC), a clinical stage oncology company focused on developing treatments that address mechanisms of therapeutic resistance. The parties aim to apply OpenBench's success-driven discovery approach and structure-based machine learning platform to enrich early discovery efforts against an undisclosed target identified by ORIC's resistance platform to target cancer-specific vulnerabilities. [...]

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OpenBench and ORIC Pharmaceuticals Launch Success-Driven Discovery Collaboration

OpenBench Assigns Leads to OnKure to Advance Pursuit of Precision Oncology Drugs

June 3, 2024

SAN FRANCISCO, June 3, 2024 /PRNewswire/ -- OpenBench, Inc., a pioneer in AI enabled success-driven small molecule discovery partnerships, today announced that it has assigned a library of promising lead compounds to OnKure, Inc., a privately held, clinical-stage biopharmaceutical company focused on the development of novel precision medicines in oncology, to advance OnKure's pursuit of an important precision oncology target. [...]

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OpenBench Assigns Leads to OnKure to Advance Pursuit of Precision Oncology Drugs

OpenBench and Related Sciences Launch Success-Driven Collaboration

June 6, 2023

SAN FRANCISCO, June 6, 2023 /PRNewswire/ -- OpenBench, Inc., a pioneer in success-driven small molecule discovery collaborations, today announced the launch of a collaboration with Related Sciences ("RS"), a data science-driven drug discovery studio, to leverage OpenBench's structure-based machine learning platform to find novel, potent chemical hit material for an initial high value RS target. [...]

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OpenBench and Related Sciences Launch Success-Driven Collaboration

Tavros Therapeutics and OpenBench Expand Strategic Collaboration for Small Molecule Drug Discovery

April 27, 2023

DURHAM, N.C. and SAN FRANCISCO, April 27, 2023 (GLOBE NEWSWIRE) -- Tavros Therapeutics, Inc., a precision oncology platform company leading the new frontier of targeted therapies exploiting tumors’ genetic vulnerabilities, and OpenBench, Inc., a screening platform pioneering success-driven small molecule discovery partnerships, today announced the companies have entered into a collaboration agreement to discover small molecule modulators of up to five oncology targets across an initial 18-month term. [...]

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Tavros Therapeutics and OpenBench Expand Strategic Collaboration for Small Molecule Drug Discovery

Success-Driven Hit Discovery Enabled by Success in the Synthesis

March 6, 2023

SAN FRANCISCO and KYIV, UKRAINE, Mar. 6, 2023 -- OpenBench, the first success-driven service for small molecule hit discovery, and Enamine, the world’s leading provider of astronomical numbers of compounds for biological screening, today announced the extension of their collaboration to enrich global early discovery efforts. [...]

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Success-Driven Hit Discovery Enabled by Success in the Synthesis

Carolina Collaborating with OpenBench to Enhance Therapeutic Discoveries

November 9, 2022

CHAPEL HILL, N.C. and SAN FRANCISCO, Nov. 9, 2022 -- The University of North Carolina at Chapel Hill’s Office of the Vice Chancellor for Research (OVCR) and Office of Technology Commercialization (OTC) have partnered with OpenBench, Inc., the first success-driven service for small molecule hit discovery, to advance drug discovery at Carolina. The partnership is focused on high-value oncology targets identified by researchers at the University. [...]

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Carolina Collaborating with OpenBench to Enhance Therapeutic Discoveries

OpenBench Teams Up with Volastra to Discover Early Research Hits

October 18, 2022

SAN FRANCISCO, Oct. 18, 2022 /PRNewswire/ -- OpenBench, Inc., a pioneer in success-driven small molecule discovery partnerships, today announced that it has entered into a success-driven collaboration with Volastra Therapeutics, Inc., an oncology company focused on exploiting chromosomal instability to treat cancer, in which OpenBench will discover novel, potent small molecule antagonists to enrich Volastra's early discovery efforts against an undisclosed cancer target. [...]

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OpenBench Teams Up with Volastra to Discover Early Research Hits

OpenBench Assigns Two AI-Discovered Series to HemoShear Therapeutics

June 7, 2022

SAN FRANCISCO, June 7, 2022 /PRNewswire/ -- OpenBench, Inc., a pioneer in success-driven hit discovery partnerships, has agreed to assign ownership of two promising chemical series to HemoShear Therapeutics, Inc., a privately held clinical stage biotechnology company, to advance HemoShear's pursuit of an undisclosed rare disease target. [...]

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OpenBench Assigns Two AI-Discovered Series to HemoShear Therapeutics

OpenBench and Tavros Therapeutics Announce Collaboration to Pursue First-in-class Cancer Target

December 2, 2021

DURHAM, N.C. and SAN FRANCISCO, Dec. 2, 2021 /PRNewswire/ -- Tavros Therapeutics, a privately held biotechnology company discovering first-in-class cancer therapies, and OpenBench, an emerging leader in AI-enabled small molecule discovery, today announced a collaboration in which OpenBench will identify novel, potent antagonists against an undisclosed cancer target that was identified by Tavros's proprietary functional genomics platform. [...]

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OpenBench and Tavros Therapeutics Announce Collaboration to Pursue First-in-class Cancer Target

OpenBench and HemoShear Therapeutics Agree to Pursue Rare Disease Target Using Artificial Intelligence

October 5, 2021

SAN FRANCISCO, Oct. 5, 2021 /PRNewswire/ -- OpenBench, Inc., an emerging leader in AI-enabled small molecule discovery, entered into an agreement with HemoShear Therapeutics, Inc., a privately held clinical stage biotechnology company, to use the OpenBench virtual screening platform to identify novel, potent inhibitors of an undisclosed rare disease target. [...]

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OpenBench and HemoShear Therapeutics Agree to Pursue Rare Disease Target Using Artificial Intelligence